| If your email does not support graphics, please access the web version of this technical bulletin. | 
|
End of Year Promotion - Buy Now, Save Big
Like any other business at this time of year, we'd prefer to see our inventory of products reduced before we close our books on 2005. Here's your chance to take advantage of a great sales promotion on selected products listed below, and in the process, see how fluorous chemistry can make your daily work easier and more efficient. There are several ways to participate between now and December 31st:
- A 10% discount will be applied to any purchase order of the selected products with a total value over USD500.
- A 25% discount will be applied to any purchase order of the selected products with a total value over USD1000.
- A 40% discount will be applied to any purchase order of the selected products with a total value over USD2500.
In addition, we will apply a 10% discount to any purchase of Fluorous Sorbents including FluoroFlash® SPE cartridges, FluoroFlash® 40micron Silica Gel, FluoroFlash® HPLC Columns and FluoroFlash® TLC Plates.
Click here to see which products are available and subject to the promotion.
Fluorous Synthesis, Purification and Immobilization: Carbohydrate Microarrays
Professor Nicola Pohl and co-workers at Iowa State
University recently reported the synthesis and arraying of carbohydrates using
fluorous tags (J. Am. Chem. Soc. 2005, 127,
13162). The work described represents a new surface patterning method to
make carbohydrate chips for bioscreening. The researchers synthesized
fluorous tagged carbohydrates, used fluorous solid phase extraction to purify
the molecules, and then directly arrayed the fluorous tagged molecules onto a
fluorous derivatized glass slide. The microarrays were incubated with FITC
labeled lectins and the resultant fluorescence analysis was found to be
reproducible and concentration dependent. This is the first report of
fluorous affinity being used as a synthesis and purification process as well as
a non-covalent immobilization method, thereby minimizing the number of
manipulations from synthesis to arraying. Professor Pohl's results also
suggest the potential for mixed microarrays of carbohydrates, peptides, and
other classes of compounds using fluorous purification and immobilization.
FTI will offer fluorous reagents for carbohydrate synthesis as well as fluorous
derivatized glass slides in the near future. Click here if you are interested in
directly receiving release date information by e-mail. 
Greater Throughput: Plate-to-Plate F-SPE
FTI researchers have recently reported increased throughput of fluorous solid phase extractions using an Argonaut VacMaster-96 system (J. Comb. Chem. 2005, 7, 893-897). The SPE station was equipped with 24 FluoroFlash® cartridges and employed for the parallel purification of reaction mixtures using fluorous reagents. Each cartridge was charged with 3g of FluoroFlash® silica gel, providing the capability of producing up to 100mg of purified small molecule per cartridge. The 24-well receiving plate has a standard footprint that can be directly concentrated in a Genevac vacuum centrifuge. The SPE system was used in the purification of three small libraries that were produced involving amine scavenging reactions with fluorous isatoic anhydride, amide coupling reactions with fluorous CDMT, and amide coupling reactions with a newly developed fluorous Mukaiyama condensation reagent (Tetrahedron Lett. 2005, 46, 6585).
Fluorous Enhanced Microwave Chemistry
Researchers led by Profs John Porco and James Panek at Boston University have reported the use of fluorous tin oxide in the formation of macrodiolides (J. Comb. Chem. 2005, 7, 673). The macrodiolides were formed by the microwave-assisted cyclodimerization of ω-hydroxy esters using catalytic tin oxides. In these reactions the fluorous tin oxide exhibited remarkably better reactivity then the dibutyltin oxide (80% vs. 27% yield). The enhanced reactivity of the fluorous tin oxide under microwave conditions may be due to the increased dipole interactions using the fluorous tin oxide. The fluorous tin oxide not only gave better yields, but also provided a more convenient method by which to remove residual tin via fluorous solid phase extraction. A library of 106 macrodiolides ranging from 11 to 23-member ring size was produced using the fluorous enhanced microwave chemistry. This work exemplifies how fluorous chemistry can improve both synthesis and separation in the production of medicinally interesting molecules.
Coming Soon...Fluorous Fmoc-tagged Amino Acids
In early 2006 FTI will roll out a new family of fluorous Fmoc-tagged amino acids in support of the peptide synthesis community. This important new class of base labile products will supplement the acid labile fluorous Z-tagged amino acids currently offered by FTI. Through our website, you can now read online about the utility of fluorous technology in peptide chemistry. Click here to receive advance information on the product release, or to let us know your exact needs.