February 2010 Technical Newsletter
February 2010 Fluorous Technical Newsletter
CEOverture
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On to the topic for today’s newsletter: areas of fluorous research that are primed and ready for commercial use. Enjoy!
Cheers,
Philip E. Yeske
President & CEO
Fluorous Technologies Inc.
Radiopharmaceuticals and Isotope Chemistry
The use of fluorous techniques in the preparation of radioimaging agents was an area of emerging interest in 2009 and its growth should continue in 2010. The need for a simple, fast, and automated purification system makes fluourous methods ideal for the production of radioisotope labelled compounds. Early efforts have been led by Prof. John Valliant’s group at McMaster University, but reports from several other groups using fluorous techniques have appeared in the literature over the last year. While there is still some work to do in improving the radiochemical yields, the stage is set for some big advances in this important area for the production of better imaging and diagnostic agents. One of the best ways to stay current on fluorous techniques in this area is to use the “isotope chemistry” tag in F-Blog.
Fluorous Proteomics
Since the seminal paper in 2005 from the Peters group at GNF, steady progress has been made in fluorous proteomics. Last year, for example, saw several groups present posters at ASMS describing sample enrichment using fluorous tagging. Pictured below is a strategy using an on-fluorous silica tagging and enrichment. We’ve experienced increased demand for our fluorous bioreagents and separation media, indicating that many more groups are now active in this area. In 2010, we anticipate substantial growth in the number of available protocols, literature reports, and experiments using fluorous methods in proteomics and metabolomics. We also anticipate exciting new applications in quantitative proteomics, activity-based profiling, and functional group-based enrichment. For more information, please visit the Life Sciences section of our website.
Custom Oligosaccharides
For many years now, getting custom peptides or oligonucleotides has been just a few clicks away. Select your sequence, your desired modifications, your amount and, thanks to automation, you’ll have your peptide or oligo in no time at all. The same cannot be said for oligosaccharides. Many promising areas of glycomics research have been hampered by the limited availability of oligosaccharides. That will change in 2010, however. A new company, LuCELLa Biosciences, Inc. has been founded to provide the carbohydrate research community with the same type of service enjoyed by the proteomics and genomics communities. Based on pioneering research of Prof. Nicola Pohl at Iowa State University, LuCELLa Biosciences will use automated synthesis along with fluorous methods to provide custom oligosaccharides. Their website is up and running and you can order the oligosaccharides you want right now!
The Fine Print
Fluorous Technologies is a chemical technology company devoted to the development and commercialization of fluorous products for the life science market. The company uses its patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. Fluorous chemistry enhances a wide range of applications, including medicinal chemistry, combinatorial chemistry, catalysis, biomolecule production, and proteomics. For more information, please visit: http://fluorous.com
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