December 2009 Technical Newsletter
December 2009 Fluorous Technical Newsletter
CEOverture
Year ends are quite often times for reflection, so below you will find a few fluorous highlights from the past year. Looking back on 2009, we can say with certainty that fluorous techniques continue to expand in breadth and depth as reflected in the number of and types of customers with which we do business. Usage of the term “fluorous” in the scientific literature provides another measure of interest,and here too 2009 represents a pinnacle. Our primary goal here at Fluorous Technologies is to translate your interests and applications into products and services of value. That is, after all, the most important reflection. Be sure to let us know how well we are doing our job.
Happy holidays to each of you, and may 2010 bring good health and prosperity.
Cheers,
Philip E. Yeske
President & CEO
Fluorous Technologies Inc.
ISoFT’09
The biggest event of the year in the fluorous community was the Third International Symposium on Fluorous Technologies that took place in Jackson Hole, WY in conjunction with the International Symposium on Fluorine Chemistry. ISoFT’09 was a great event that provided researchers from around the world a chance to learn more about the latest developments in fluorous chemistry. Prof. Ilhyong Ryu was this year’s recipient of the Fluorous Award for his work in fluorous chemistry, particularly phase vanishing reactions. The posters and presentations highlighted the expanding role of fluorous techniques in chemistry and biology, including therapeutic peptides, oligosaccharide synthesis, materials chemistry, and microarraying. If you missed ISoFT’09, you can catch up on all of the events and also view many of the posters and presentations through F-Blog or on our presentations page. Also keep in mind that ISoFT’11 will be held in Hong Kong. See you there!
Cover Stories
Fluorous chemistry was an integral part of two papers in 2009 that were chosen as journal cover stories. The first was in January when Prof. Veronique Gouverneur’s work using fluorous methods for the preparation of radiopharmaceuticals graced the cover of Angewandte Chemie, Internat. Ed. She described the use of fluorous sulfonates as electrophiles in 18F substitution reactions. The excess sulfonate could then be easily separated using fluorous solid phase extraction (FSPE) maximizing the yield relative to the 18F. Later in the year, Prof. Nicolas Winssinger’s group used fluorous mixture synthesis (FMS) and a fluorous Mitsunobu reaction in library synthesis and SAR determination of resorcylic macrolactones. This work was highlighted on the cover of Chemistry – A European Journal. In both instances the ease and simplicity of fluorous techniques was instrumental to the success of the projects.
Fluorous Technologies Inc. can provide you with all the tools and expertise necessary so you can take advantage of fluorous chemistry to achieve your research goals.
Fluorous Techniques in Proteomics
Fluorous enrichment strategies for proteomics were presented by three different research groups at the American Society of Mass Spectrometry (ASMS) meeting in June. All three groups used fluorous tagging for the enrichment of selective peptide subsets. Prof. Mark McComb’s group has followed-up their poster with a paper describing a fluorous tag in conjunction with reverse phase HPLC for cysteinyl peptide enrichment. Dr. Eric Peters’ group meanwhile combined fluorous enrichment with click chemistry in a novel on-fluorous silica approach to cysteinyl peptide enrichment.
Fluorous enrichment provides a novel bioorthogonal separation method that provides affinity-like separation with high selectivity and low non-specific binding. Contact us to learn how to apply this technique in your proteomics and metabolomics research.
Immobilization on Fluorous Glass Slides
This year also saw an increase in the use of fluorous modified surfaces for the immobilization of fluorous tagged molecules. Some of the more interesting reported applications include a peptide based microarray for determination of protease activity, the use of click chemistry on a fluorous glass slide, and the detection of fluorous tagged DNA by aggregation of gold nanoparticles on a fluorous modified surface. All of these applications took advantage of the low non-specific binding and low background fluorescence of fluorous glass slides. Fluorous tagging together with fluorous immobilization provides an integrated approach to content generation and screening through the use of a single tag, thereby simplifying the entire process. Simpler and better!
Fluorous Technologies Inc. Advances
We continued to refine and expand our operations in 2009 in order to better serve you, our chemistry and biology customers. Our most visible change was the launch of a new website. The website was designed around three major areas: small molecule synthesis, biomolecule synthesis, and life sciences applications. We’ve also updated the Technology section, the Presentations page, and the EndNotes references to provide users the most comprehensive site possible. So whether you want to learn more about fluorous chemistry in peptide chemistry, microarraying, or library synthesis, the first place to go is fluorous.com.
Thanks for the feedback and please continue to let us know how to better your experience on fluorous.com.
The Fine Print
Fluorous Technologies is a chemical technology company devoted to the development and commercialization of fluorous products for the life science market. The company uses its patented technology to solve synthesis and separation problems spanning the entire drug discovery and development process. Fluorous chemistry enhances a wide range of applications, including medicinal chemistry, combinatorial chemistry, catalysis, peptide and oligonucleotide production, and proteomics. For more information, please visit: http://fluorous.com
For questions, quotes, orders, product availability, and access to technical resources, please email us or call 412-826-3050.
Fluorous Technologies Inc. is located at 970 William Pitt Way, Pittsburgh, PA 15238 USA.
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