February 2009 Technical Newsletter
February 2009 Fluorous Technical Newsletter
CEOverture…
Dear Reader,
Our goal as a company is to fully satisfy our customers, the life sciences research community. Toward this end we’re taking steps in 2009 to make interacting with Fluorous Technologies easier. For instance, soon our website at fluorous.com will feature a clearer interface for a wide range of visitors to navigate- whether looking to learn more about fluorous technology in general, or finding detailed support regarding a specific application, or desiring to purchase products. Regardless of your reason for visiting fluorous.com we want to make your time spent on the website more valuable to you- look for continuous rollouts this year of new and improved information about our company and our offering. Lastly, we are occasionally asked about accepting credit cards for product purchases, and while there is an administrative and financial penalty to be paid for us to do that, the customer has spoken- you want it. We’re researching the options and expect to offer this expanded payment capability later this calendar quarter.These steps, both small and big, are intended to make Fluorous Technologies an even more useful and trusted supplier of research tools to you, our valued customer. We always welcome your input on any subject relating to Fluorous Technologies at feedback@fluorous.com.
Cheers,
Phil
Angewandte Chemie, Intl. Edition Cover Story
For the first time, the January 5th 2009 cover of Angewandte Chemie, Intl. Ed. featured fluorous chemistry. The cover article described the formation of 18F PET radioimaging agents using fluorous techniques. 18F is often introduced into molecules through nucleophilic substitution of a sulfonate. The sulfonate is most often used in large excess in order to maximize the yield of the resultant product relative to the amount of 18F used. Removal of the sulfonate is then necessary to obtain high purity material. The short half-life of 18F (~110 min) requires that syntheses and purifications be fast and effective. Researchers from labs at the University of Oxford, AstraZeneca, and Siemens Molecular Imaging recognized that a fluorous sulfonate could meet these requirements. The fluorous sulfonate was used in excess during the reaction with 18F anion, and it was easily and quickly separated from the radioimaging agent by fluorous solid phase extraction (FSPE).
Congratulations to the research team for a great application of fluorous techniques and for the recognition they have received.
New Application Notes for Life Sciences
Two new application notes are now available on our website. The Fluorous NuTip Protocol (pdf) is a note for the use of fluorous NuTips, our pipette tip formatted with fluorous silica gel for use in biological sample enrichment. The NuTips are available in two sizes and are used in conjunction with fluorous bioreagents. Fluorous Technologies Inc. provides a complete line of fluorous tags including NHS esters for amine tagging and fluorous maleimides for cysteine tagging. The tagged components from a complex mixture can then be enriched by FSPE using the fluorous NuTips. If you would prefer to conduct the FSPE enrichment in a different format, Fluorous Technologies also supplies fluorous silica gel in a microLC trap cartridge format or as bulk silica gel to provide a variety of options.
The second application note, Fluorous Microarray Protocol (pdf), is for the use of fluorous-coated glass slides to immobilize fluorous-tagged compounds. The application note is a compilation of existing reports in the literature where carbohydrates and small molecules have been rendered fluorous and immobilized onto a fluorous glass surface. Our exclusive fluorous-modified glass slides, available in either bar-coded or plain versions, are produced according to the highest standards by Thermo Fisher Scientific, a world leader in microarray slide production. Fluorous microarrays are characterized by very low non-specific binding, low and uniform background fluorescence, and high signal-to-noise ratios. In other words, everything you’re looking for in an immobilization technique.
Fluorous.com Under Construction
We’re putting the final touches on a new version of fluorous.com. The new website will better reflect our focus on solving your problems in Small Molecule Synthesis, Biomolecule Synthesis, and Life Science Applications. Expect expanded sections on proteomics, microarraying, and peptide synthesis. If there is something you’d like to see on the new fluorous.com, please let us know!
2009 Spring American Chemical Society Meeting
Dr. Marvin S. Yu of Fluorous Technologies will be giving an oral presentation entitled “Solvent Tuning for Improved Fluorous Liquid-liquid Extractions” at the Spring ACS Meeting to be held in Salt Lake City, Utah from March 22-26th. This presentation will be part of the ACS Industrial Award Symposium recognizing this year’s Award recipient, Dr. George Moore of 3M. Fluorous Technologies is pleased to be involved in honoring Dr. Moore for his many accomplishments in fluorochemistry.
Our next newsletter will highlight many of the other oral presentations and posters that will be presented at the ACS Meeting using fluorous techniques. In addition, if you would like meet with Dr. Yu to discuss any matters related to fluorous technologies or chemistry, please feel free to contact us to arrange a meeting.
We look forward to seeing you there!
ISoFT’09 Update
Fluorous Technologies is a proud sponsor of the 19thISFC-ISoFT’09. As such, we’d like to pass along the following important conference information.
Call for Papers
The organizers of the 19thISFC-ISoFT’09 are pleased to announce a call for papers for the 19th Int’l. Symposium on Fluorine Chemistry, which will be held from August 23–28, 2009, at the Jackson Lake Lodge in northwest Wyoming. The triennial ISFC is the premier conference on fluorine chemistry in the world, typically bringing together 300–400 chemists from dozens of countries for a week of lectures, poster presentations, and informal discussions during organized social activities. For the first time, the ISFC will be held in conjunction with the biennial Int’l. Symposium on Fluorous Technologies. The combined 2009 19thISFC-ISoFT’09 conference will offer even more opportunities than usual for scientific discussion, networking, and potential collaboration across sub-disciplines of fluorine chemistry and between academic, industrial, and government-lab scientists. There will be technical sessions on alternative energy and energy storage, environmental and analytical chemistry, fluorine in medicine, biochemistry, and agriculture, fluorous technologies, fluoropolymers and other materials, and general sessions on organic, inorganic, organometallic, and physical/computational chemistry.
The conference website, at http://www.chm.colostate.edu/shs/19isfc.htm, has links for conference registration, housing , and abstract submission (the deadline for abstract submission is April 30th, 2009). Early registration fees are: $575 for Participants; $250 for Student Participants; and $250 for Accompanying Persons (the deadline for early registration is April 30th, 2009). A number of travel fellowships for students and postdocs who present their work will be available, and the best student/postdoc posters will receive cash awards. The conference website also lists the Plenary Lecturers and Keynote Speakers that have accepted invitations to date and includes other deadlines, information about the accompanying persons program, a list of sponsors, and much more.
Read more from the official Call for Papers (pdf) document.
Abstract Submission
Abstract submission for 19thISFC-ISoFT’09 is now open. The deadline for abstract submission is April 30th, 2009. The categories are (in no particular order):
- Other Topics
- Physical/Theory
- Fluorous Technologies
- Environmental/Analytical
- Bio/Medical/Agrochemicals
- Alternative Energy/Energy Storage
- Fluoropolymers/Other Materials/Industrial Processes
- Organic/Organometallic (including the Tatlow memorial session)
- Inorganic/Organometallic (including the Bartlett memorial session)