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FluoroFlash® NuTips  

Fluorous Silica Gel   

TLC Plates

Fluorous Modified Glass Slides

LC Trap Cartridges

 

The separation of fluorous compounds from non-fluorous compounds using FluoroFlash® silica gel is the central theme of fluorous techniques.  Under the appropriate conditions the FluoroFlash® stationary phase retains the fluorous compounds with exceptional efficiency and selectivity.  A simple switch of the mobile phase then effects release of the fluorous compounds from the stationary phase.  FluoroFlash® silica gel is characterized by its high loading capacity, outstanding selectivity, and easy recyclability (1-2).

 

FluoroFlash® silica gel is available in a vareity of formats from analytical to preparative and from pre-packaged to loose bulk.  FTI can also custom format FluoroFlash® silica to meet your purification needs. Just click on the 'Contact Us' button above and let us know the format that you need!

 

1. 'Separations with Fluorous Silica Gel and Related Materials' in Handbook of Fluorous Chemistry Gladysz, J. A.; Curran, D. P.; Horvath, I. T. Eds. Wiley-VCH, 2004,  pp101-155.

2. D. P. Curran, Synlett 2001, 1488-1496.

 
SPE cartridges
 

Fluorous solid phase extraction (F-SPE) is used for quick separations of reaction mixtures involving fluorous catalysts, reagents, protecting groups, tags, and scavengers (1-6).  F-SPE is used for quick separations of reaction mixtures involving FluoroFlash® tags, reagents, scavengers and catalysts.  The separation of fluorous compounds by F-SPE is a reliable and generic procedure that more greatly resembles filtration than chromatatography.  The facile separation depends primarily on the presence or absence of a light fluorous tag, not polatity or other molecular features that control traditional chromatography.

A simple two-step separation of fluorous compounds involves the loading of a reaction mixture containing the fluorous-tagged molecule on to an F-SPE cartridge, washing the non-fluorous compounds away using a fluorophobic wash, then washing the fluorous compounds with a fluorophilic wash.  Please consult the F-SPE application note for a more detailed procedure.

FluoroFlash® SPE cartridges are pre-packed in a variety of formats with a proprietary fluorous silica gel.  A Fluorous Dye Separation Kit (cited on the F-SPE Application Note) is available to demonstrate how the F-SPE works. If you require a particular format, i.e. specific cartridge size, multi-well plate, etc., please contact FTI. 

 

1. Zhang, W.; Curran, D. P. Tetrahedron 2006, 62, 11837–11865.

2. Curran, D. P. Handbook of Fluorous Chemistry, 2004, 101-155.

3. Zhang, W.; Curran, D. P.; Chen, C. H.-T. Tetrahedron, 2002, 58, 3871-3875.

4. Curran, D.; Lou, Z. Y. Green Chem. 2001, 3, G3-G7.

5. Zhang, Q.; Luo, Z.; Curran, D. P. J. Org. Chem. 2000, 65, 8866-8873.

6. Curran, D. P.; Hadida, S.; He, M. J. Org. Chem. 1997, 62, 6714-6715.

 

NAME/CAS# CATALOG# QTY PRICE
FluoroFlash® SPE Cartridges, 2 grams, 8 cc tube (2)  
801-0027S-2 Ea Inquire
 
FluoroFlash® SPE Cartridges, 2 grams, 8 cc tube (5)  
801-0027S-5 Ea Inquire
 
FluoroFlash® SPE Cartridges, 2 grams, 8 cc tube (20)  
801-0027S-20 Ea Inquire
 
FluoroFlash® SPE Cartridges, 5 grams, 10 cc tube (2)  
801-0058S-2 Ea Inquire
 
FluoroFlash® SPE Cartridges, 5 grams, 10 cc tube (10)  
801-0058S-10 Ea Inquire
 
FluoroFlash® SPE Cartridges, 10 grams, 60 cc tube (1)  
801-0109S-1 Ea Inquire
 
FluoroFlash® SPE Cartridges, 10 grams, 60 cc tube (5)  
801-0109S-5 Ea Inquire
 
FluoroFlash® SPE Cartridges, 20 grams, 60 cc tube (1)  
801-0209S-1 Ea Inquire
 
FluoroFlash® SPE Cartridges, 20 grams, 60 cc tube (5)  
801-0209S-5 Ea Inquire
       
Fluorous Separation Trial Kit Includes F-Orange™ fluorous dye (~5mg), Solvent Blue™ non-fluorous dye (~5mg), F17 Cbz-OSu tag (500 mg), F17 Thiol scavenger (500 mg), 2g F-SPE cartridges (2 cartridges) Ea Inquire