Like FSPE, Fluorous High Performance Liquid Chromatography utilizes FluoroFlash silica, packed as an HPLC column, as the fluorous phase to extract fluorous molecules. FHPLC, however, goes beyond FSPE and separates fluorous molecules from other fluorous molecules based on fluorous content. Fluorous molecules can be differentiated from each other by the length of the fluorous chain or the number of fluorous chains. The more fluorine atoms present, the greater the retention time of the fluorous HPLC column.
The separation of fluorous molecules from each other can sometimes be accomplished by standard chromatographic techniques, including traditional or reverse phase chromatography. However, the best way to separate fluorous compounds from each other is usually by chromatography over FluoroFlash® fluorous silica.
FluoroFlash® HPLC columns are packed with a proprietary fluorous silica gel specifically designed for HPLC applications. Under F-
Fluorous High Performance Liquid Chromatography (FHPLC)
An illustrative example of F-
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