Fluorous Applications




Scavengers and Reagents

Benefits of FluoroFlash Scavengers and Reagents

  • Accelerate your workflow with solution phase kinetics
  • Easily remove excess reagents and unwanted byproducts with fast, robust, and universal methods
  • Quickly get the purity you need for time-sensitive applications
  • Eliminate guesswork by monitoring your reactions using standard analytical techniques

Fluorous Scavengers

Scavengers and Reagents

ln many reactions, an excess of starting materials is used to drive a solution phase reaction to completion. The final mixture is composed of the desired product and one or more byproducts (either excess reagents and/or spent reagents). The soluble FluoroFlash® scavenger is then introduced and scavenges the byproducts to form fluorous-tagged compounds. Rapid F-SPE of the reaction mixture retains the scavenged byproducts and any unreacted scavenger while allowing the target product to be isolated easily and rapidly.[1] A range of FluoroFlash® scavengers are available including both nuclephilic and electrophilic scavengers to fit your exact needs.

Fluorous Reagents

Fluorous reagents offer many of the same benefits as fluorous scavengers; solution phase kinetics, precise control of stoichiometry, and ease of by-product removal by fluorous solid phase extraction.[2] The functional groups perform as their non-fluorous version with the added benefit of easy FSPE separation of byproducts and unreacted reagents. Our most popular fluorous reagents include fluorous DIAD and fluorous triphenylphosphine for Mitsunobu reactions[3] and fluorous tin hydrides for deoxygenations and free radical reactions.

Superior to Solid Phase Scavengers and Reagents

Scavengers and Reagents

Side-by-side comparisons have shown that FluoroFlash® scavengers and reagents outperform solid phase analogs in terms reaction kinetics and amount used.[4] FluoroFlash® scavengers and reagents are fully soluble in most organic solvents resulting in solution phase kinetics and complete reaction using lower amounts of scavenger or reagent. Since FluoroFlash® scavengers and reagents are molecules, not materials, precise stoichiometric control can be achieved, reactions can be monitored, and the scavengers and reagents easily checked to ensure reactivity.

Fluorous Separations Speed up Radiolabeling Agent Synthesis

Every second counts in the synthesis of radiolabeled imaging agents with short half lives. To beat the clock, many researchers turn to fluorous scavengers and reagents. Professor Valliant at McMaster University introduced iodine isotopes using fluorous tin compounds. Prof. Véronique Gouverneur and co-workers incorporated fluorous tags in their synthesis of 18F radioimaging agents. In both cases, FSPE easily and rapidly removed unwanted starting materials and other impurities to acheive high effective specific activity.

Accelerate Your Research Today

Fluorous Technologies Inc. provides a range of scavengers and reagents to meet nearly all of your synthetic needs. View our product offering by visiting the links listed under Related Products. We've also provided a wealth of documentation about fluorous scavenging and reagents under the For More Information section.

Selected References

  • Lindsley, C. W.; Leister, W. H. Handbook of Fluorous Chemistry 2004, 236-246.
  • Curran, D. P. Aldrichimica Acta 2006, 39, 3-9.
  • Dandapani, S.; Curran, D. P. Journal of Organic Chemistry 2004, 69, 8751-8757
  • Lindsley, C. W.; Zhao, Z.; Newton, R. C.; Leister, W. H.; Strauss, K. A. Tetrahedron Letters 2002, 43, 4467-4470